OpenVigil2_logo

OpenVigil - open tools for data-mining and analysis of pharmacovigilance data

Search drugs and adverse events with OpenVigil 2! Search drugs and adverse events with OpenVigil FDA!) Explore AERS with OpenVigil 1!

Welcome About Pharmacovigilance How to use OpenVigil Technical docs and other resources Further Literature News & project roadmap

What is OpenVigil?

OpenVigil 1 and 2 are software packages to analyse pharmacovigilance data. There are several national and international databases of so called spontaneous adverse event reports, e.g., the U.S. american FDA Adverse Event Reporting System (AERS, mostly domestic data) or the WHO Uppsala Monitoring Centre (international). Currently, analyses of FDA AERS (LAERS & FAERS) pharmacovigilance data are available. In addition to U.S. american data, we are currently importing German data. Data mining features include highly configurable search criteria filters and output filters. Analyses include disproportionality analyses like Proportional Reporting Ratio (PRR) calculations. Results can be viewed, sorted and filtered in the webbrowser or saved for further analyses in statistical software packages. Both projects aim at integrating these and other pharmacolovigilance sources to pharmacoepidemiological data like prescription data.
OpenVigilFDA is a fron-end to the openFDA-interface which is being developed by the FDA since 2014. It allows you to extract the latest reports. Due to technical limitations of openFDA, OpenVigil 2 is superior for analyses of disproportionality.

Where can I access OpenVigil?

There are live installations with FDA data of both versions of OpenVigil with FDA AERS data and OpenVigilFDA freely available at Christian Albrecht University (CAU) of Kiel, Germany:

OpenVigil 2: http://www.is.informatik.uni-kiel.de:8503/OpenVigil/search/
(currently requires prior registration, please email us!)
(If you cannot reach the application, make sure that port 8503 is not blocked by your institution or internet provider.)

OpenVigil FDA: http://www.uni-kiel.de/pharmacology/pvt/openvigilfda.php
(development version at: http://www.uni-kiel.de/pharmacology/pvt/openvigil-current.php)

OpenVigil 1: http://www.uni-kiel.de/pharmacology/pvt/openvigil.php
(development version at: http://www.uni-kiel.de/pharmacology/pvt/openvigil-current.php)


OpenVigil 2 and OpenVigilFDA are the successors of OpenVigil 1 and use cleansed FDA AERS data. For scientific research on U.S. american data, do not use OpenVigil 1 but only version 2 or OpenVigilFDA!

There is also a development version of German pharmacovigilance data available for preview:
OpenVigil 1 German: http://www.uni-kiel.de/pharmacology/pvt/openvigil-current-bfarm.php)
The german pharmacovigilance data are of sufficient quality and do not need further drugname-mapping prior to mining or analysing them.

Where can I download OpenVigil?

You can download OpenVigil 1, OpenVigilFDA and soon OpenVigil 2 at sourceforge: http://sourceforge.net/projects/openvigil/

Who can be contacted about this project?

The project is maintained by Dr. R. Böhm, Institute of Experimental and Clinical Pharmacology, UKSH Kiel, <ruwen.boehm@pharmakologie.uni-kiel.de> and Prof. H.J. Klein, Institut für Informatik, Christian Albrechts University, Kiel, <hjk@is.informatik.uni-kiel.de>

Both OpenVigil 1 and 2 use browser cookies.
Responsible for this website (Impressum / Betreiber der Website): Dr. med. Ruwen Böhm, Institut für Experimentelle und Klinisch Pharmakologie, UKSH Kiel, Hospitalstr. 4, 24105 Kiel, Germany. Tel. +49 431 597 3510.
Due to the origin and nature of the data and the ongoing work on our programs, all results should be considered unvalidated. However, these data are usable for hypothesis generation.